Browsing Biochemistry and Microbiology by Title

Now showing items 39-58 of 72

Genome data mining, identification, annotation and phylogenetic analysis of P450s in pathogenic fungus Conidiobolus coronatus

Ngwenya, Mathula Lancelot (University of Zululand, 2018)

Conidiobolus coronatus, an entomopathogenic fungus, has the ability to infect humans and other animals (human, horse, sheep and dog), apart from insects. C. coronatus causes conidiobolomycosis in humans, which is considered ...
Glycemic control and pancreatic beta cells protective effect of a lanosteryl triterpene from Protorhus longifolia in hyperlipidemic and STZ-induced diabetic rats

Mabhida, Sihle E. (University of Zululand, 2018)

Prevalence of diabetes mellitus (DM), a chronic metabolic disorder of carbohydrates and lipids that is characterized by persistent hyperglycemia, is rapidly reaching epidemic levels. Hyperglycemia-induced oxidative stress ...
Identification and structural bioinformatics of druggable proteins in schistosoma species

Aruleba, Raphael Taiwo (University of Zululand, 2018)

Schistosomiasis is a debilitating disease caused by a parasitic flatworm found in freshwater. After malaria, this disease is the second most prevalent disease in Africa and is endemic in both tropical and sub-tropical ...
In vitro and in vivo effect of aspalathus linearis and its major polyphenols on carbohydrate and lipid metabolism in insulin resistant models

Mazibuko, Sithandiwe Eunice (University of Zululand, 2014)

High levels of saturated fatty acids (SFAs), such as palmitate, are associated with insulin resistance of muscle, fat and liver. Skeletal muscle, which accounts for up to 80% of peripheral glucose disposal, is particularly ...
An in vitro and in vivo hepatotoxicity study of an aspalathin- rich green rooibos extract

Buthelezi, Ntandoyenkosi Nokuthula (University of Zululand, 2018)

Hepatotoxicity is an undesirable condition of the liver, often occurring due to the interaction of drugs. Although different methods have been employed in the diagnosis of drug-induced hepatotoxicity, none have accurately ...
In vitro anti-platelet aggregation activity of the extracts of bulbine natalensis

Lazarus, Geraldine Genevive (2011)

Bulbine natalensis Baker is a medicinal plant with succulent, aloe-like leaves from the Asphodelaceae family, commonly used by Zulu traditional healers to treat blood clotting-related diseases. The aim of this research ...
In vitro anti-platelet aggregation activity of the extracts of protorhus longifolia

Mosa, Rebamang Anthony (2011)

Platelet aggregation beyond purpose of haemostasis is the underlying cause of blood-clotting related diseases. Concoctions of P. longifolia are used by Zulu traditional healers to manage such diseases. This work aimed ...
In vitro assessment of cytochrome P450 and drug transporters modulation by polyphenolic constituents of cyclopia genistoides

Mchunu, Nonkululeko Purity Nokuphila (University of Zululand, 2019)

Historically, medicines were administered in the form of herbal concoctions, and this is still true for many traditional medicines. These ancient remedies are often consumed straight from the bush/bark or leaf, ground ...
An in vitro assessment of the potential toxicity of Cadmium Selenide nanoparticles

Dunpall, Rekha (2012)

Nanotechnology is steadily finding its application in all aspects of the consumer industry, science and engineering. At a relative pace Cadmium Selenide (CdSe) nanoparticles are gaining increased attention for their ...
An in vitro study of the effects of free fatty acids on insulin mediated glucose uptake and metabolism by myocytes and fibroblast derived adipocytes

Mazibuko, Sithandiwe Eunice (2011)

The incidence of type 2 diabetes (T2D) is increasing at an alarming rate, especially in developing countries, including South Africa. In developing countries, changes in lifestyle, especially the increase in the consumption ...
Intestinal absorption and metabolism of bush tea major phenolic compounds exhibiting anti-diabetic activity.

Ntamo, Yonela (University of Zululand, 2017)

Athrixia phylicoides (A. phylicoides), popularly known as ‘bush tea’, is an indigenous aromatic shrub found in mountainous and grassland areas of the northern and eastern parts of Southern Africa. The plant is traditionally ...
Investigating the effect of aspalathus linearis as a cardio-protective therapy in isolated rat cardiomyocytes

Dludla, Phiwayinkosi Vusi (University of Zululand, 2013)

Diabetic cardiomyopathy (DCM) is a common disorder of the heart muscle and it contributes significantly to cardiovascular related deaths in the diabetic population. Excess generation of free radical species due hyperglycaemia ...
Investigation of Interaction between heat shock protein 70.14 (Hsp 70.14) and RBBP6 RING finger domain

Ikwegbue, Paul (University of Zululand, 2019)

Despite improvement in cancer treatment modalities, cancer remains one of the leading causes of death worldwide. Studies show that in 2012, about 14.1 million new cancer cases resulting in 8.2 million deaths were reported ...
Investigation of pathogens removal from wastewater using a hydroponic system

Ndulini, Sinqobile Fanele (University of Zululand, 2017)

Microbial contamination in water sources is a threat to public health and environment. It may lead to distribution of pathogenic microorganisms in water, which may lead to waterborne diseases outbreaks. The current municipal ...
Isolation and characterization of bacteria recovered from wounds of hospitalized diabetic patients in Northern KwaZulu-Natal

Mthembu, Wendy (University of Zululand, 2016)

Diabetes mellitus is a world health concern with about 2.28 million cases recorded in South Africa in 2015. One of the complications of diabetes is the development of chronic wounds that contribute to longer hospitalization ...
Lactogenic activity of Gunnera perpensa L. (Gunneraceae) from South Africa

Simelane, Mthokozisi B.C (2010)

Gunnera perpensa L. (Gunneraceae) is a medicinal plant used by Zulu traditional healers to induce labor, expel the placenta after birth, to relieve menstrual pains, and to stimulate milk production. Phytochemical screening ...
Metabolic Bioactivity of Athrixia phylicoides

Masilela, Charity Mandisa (University of Zululand, 2017)

BACKGROUND: Insulin resistance is a major risk factor for the development of type 2 diabetes (T2D). It is characterized by insufficient response to secreted insulin in target tissues. In vitro studies demonstrated the ...
Microbiological evaluation of the Mhlathuze River in KwaZulu-Natal

Mthembu, Nompumelelo (2004)

High levels of faecal coiifonns pose a treat to the health of the rural community that uses the river water directly for domestic use without treatment. The microbiological, physical and chemical analysis of the Mhiathuze ...
Molecular cloning, recombinant protein expression and structural characterization of a universal stress G4LZI3 protein from Schistosoma mansoni

Adenowo, Abiola Fatimah (University of Zululand, 2018)

Human schistosomiasis is a primary tropical disease caused by the larvae of a blood fluke parasite called schistosome. Different species of schistosomes are responsible for various types of schistosomiasis but most of the ...
Neuroprotective Potential of a Lanosteryl Triterpene from Protorhus longifolia Stem Bark (Benrh.) Engl in high fat diet fed and STZ -induced diabetic neuropathy in rats

Ndlovu, Musawenkosi (University of Zululand, 2019)

Chronic hyperglycemia, observed in the diabetic state, is responsible for various diabetes related complications including development of diabetic nephropathy. Diabetic neuropathy development and progression is linked to ...

Now showing items 39-58 of 72

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