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Anti-diabetic properties of GUH

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dc.contributor.advisor Opoku, A.R.
dc.contributor.advisor Louw, J.
dc.contributor.advisor Woodroof, C.
dc.contributor.author Gabuza, Kwazi B.
dc.date.accessioned 2010-06-17T10:16:58Z
dc.date.available 2010-06-17T10:16:58Z
dc.date.issued 2006
dc.identifier.other 304885
dc.identifier.uri http://hdl.handle.net/10530/330
dc.description Dissertation submitted in partial fullfilment of the requirements for the Master of Science Degree in the Department of Biochemistry and Microbiology in the Faculty of Science and Agriculture at the University of Zululand, 2006. en_US
dc.description.abstract Objective: To investigate anti-diabetic properties of the plant extract known as GUH in comparison to commercially available drugs metformin and rosiglitazone. Methods: Male Wistar rats were fed a maintenance diet (MD) with tap water or a high fat diet (HFD) with sucrose solution for a period of twelve weeks. Thereafter a separate groups of animals were then treated with GUH at 5 different dose levels, metformin or rosiglitazone for twelve weeks. Food intake, liquid intake, weights, blood glucose, and insulin were monitored throughout the treatment period. An intravenous glucose tolerance test (IVGTT) was performed on representative animals from each treatment group prior to termination. At termination blood was taken and total cholesterol, tri-acylglycerol (TAG), low density lipoproteins LDL, and high density lipoproteins (HDL) were measured. Results: The effect of GUH in MD fed rats was not marked. However, food intake and weight gain and total cholesterol were lower than in control animals. In HFD fed animals GUH, metformin and rosiglitazone had a significant effect The extract reduced blood glucose and increased circulating insulin levels when compared to controls but results were not significantly different to metformin and rosiglitazone treated animals. As with metformin and rosiglitazone, GUH increased food intake with a concomitant weight increase. This weight increase was, nevertheless, less than with the other 2 treatments. In HFD fed animals GUH at the highest dose level increased the glucose clearance rate to a greater extent than metformin and rosiglitazone. Conclusion: The results conclusively show that the extract GUH was at least as effective, and in some instances more effective, than currently used diabetes treatments. Although further work is required to investigate the mode of action, it is evident that extracts of indigenous South African plants can be cost effective and efficacious treatments. en_US
dc.description.sponsorship Medical Research Council en_US
dc.language.iso en en_US
dc.subject Diabetic drugs en_US
dc.subject GUH en_US
dc.title Anti-diabetic properties of GUH en_US
dc.type Thesis en_US

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