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In vitro and in vivo effect of aspalathus linearis and its major polyphenols on carbohydrate and lipid metabolism in insulin resistant models

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dc.contributor.advisor Muller, C.
dc.contributor.advisor Opoku, A.
dc.contributor.advisor Joubert, E.
dc.contributor.author Mazibuko, Sithandiwe Eunice
dc.date.accessioned 2014-06-23T10:01:46Z
dc.date.available 2014-06-23T10:01:46Z
dc.date.issued 2014
dc.identifier.uri http://hdl.handle.net/10530/1319
dc.description A thesis submitted in fulfilment of the requirements for the degree of Doctor of Philosophy in Biochemistry at the Faculty of Biochemistry and Microbiology, University of Zululand, South Africa, 2014. en_US
dc.description.abstract High levels of saturated fatty acids (SFAs), such as palmitate, are associated with insulin resistance of muscle, fat and liver. Skeletal muscle, which accounts for up to 80% of peripheral glucose disposal, is particularly vulnerable to increased levels of SFAs. Rooibos (Aspalathus linearis) and its unique dihydrochalcone C-glucoside, aspalathin, shown to reduce hyperglycemia in diabetic rats, could play a role in preventing or ameliorating the development of insulin resistance. This study aims to establish whether rooibos and its major phenolic compounds (aspalathin, orientin, isoorientin and rutin) can ameliorate palmitate-induced insulin-resistance in C2C12 skeletal muscle cells, 3T3-L1 adipocytes and in C3A liver cells. The efficacy of rooibos will also be assessed in an obese insulin-resistant (OB/IR) rat model. en_US
dc.description.sponsorship South African Medical Research Council, National Research foundation and the University of Zululand. en_US
dc.language.iso en en_US
dc.publisher University of Zululand en_US
dc.subject Insulin resistant en_US
dc.title In vitro and in vivo effect of aspalathus linearis and its major polyphenols on carbohydrate and lipid metabolism in insulin resistant models en_US
dc.type Thesis en_US


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