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Synthesis, characterisation and in vitro studies of metal complexes of some selected antimalarial drugs

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dc.contributor.advisor Kalawole, G.A.
dc.contributor.author Ajibade, Peter Adewale.
dc.date.accessioned 2013-02-07T10:07:02Z
dc.date.available 2013-02-07T10:07:02Z
dc.date.issued 2005
dc.identifier.uri http://hdl.handle.net/10530/1140
dc.description Thesis submitted in fulfilment of the requirement for the award of the degree of Doctor of Philosophy in the Department of Chemistry at the University of Zululand, South Africa, 2005. en_US
dc.description.abstract This project deals with the synthesis, characterization and in vitro studies of metal complexes of antimalarial drugs. The synthetic techniques were based on the modification of antimalarial drugs by the introduction of metal ions into the molecular structure of the drugs. Thirty two metal complexes derived from chloroquine, amodiaquine, trimethoprim, sulfadiazine, tetracycline and pyrimethamine have been synthesised using the following metal ions: Co(II), Cu(II), Zn(II), Mn(II), Ni(II), Pt(II), Pd(II), Co(III), Fe(III), Ru(III) and VO(II). The complexes were characterised by melting point / decomposition temperature, solubility, conductivity measurement, elemental analyses, UV-Vis and IR spectroscopy, mass spectrometry, magnetic susceptibility measurement and EPR. Six of the complexes and sulfadiazine ligand were also characterised by single X-ray crystal studies. The complexes were screened in vitro against four isolates of Plasmodium falciparum at various stages of the parasites development The results showed that three of the metal complexes, cobaIt(III)amodiaquine, cobalt(III)quinacrine and iron(III)amodiaquine are more active in vitro against the parasites in comparison to chloroquine the first drug of choice for treatment of chloroquine falciparum malaria in Africa. en_US
dc.description.sponsorship National Research Foundation (NRF) & Royal Society en_US
dc.language.iso en en_US
dc.publisher University of Zululand en_US
dc.subject Drugs--Physiological effect. en_US
dc.subject Metal complexes--Evaluation. en_US
dc.subject Antimalarials. en_US
dc.title Synthesis, characterisation and in vitro studies of metal complexes of some selected antimalarial drugs en_US
dc.type Thesis en_US

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