In vitro and in vivo effect of aspalathus linearis and its major polyphenols on carbohydrate and lipid metabolism in insulin resistant models
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Date
2014
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Publisher
University of Zululand
Abstract
High levels of saturated fatty acids (SFAs), such as palmitate, are associated with insulin resistance of muscle, fat and liver. Skeletal muscle, which accounts for up to 80% of peripheral glucose disposal, is particularly vulnerable to increased levels of SFAs. Rooibos (Aspalathus linearis) and its unique dihydrochalcone C-glucoside, aspalathin, shown to reduce hyperglycemia in diabetic rats, could play a role in preventing or ameliorating the development of insulin resistance. This study aims to establish whether rooibos and its major phenolic compounds (aspalathin, orientin, isoorientin and rutin) can ameliorate palmitate-induced insulin-resistance in C2C12 skeletal muscle cells, 3T3-L1 adipocytes and in C3A liver cells. The efficacy of rooibos will also be assessed in an obese insulin-resistant (OB/IR) rat model.
Description
A thesis submitted in fulfilment of the requirements for the degree of Doctor of Philosophy in Biochemistry at the Faculty of Biochemistry and Microbiology, University of Zululand, South Africa, 2014.
Keywords
Insulin resistant